The lead changed hands several times in a contest that featured 28 hits and seven home runs between the two programs. The Red Storm (8-13, 5-9 Big East) fell for the second straight game to the Bluejays (12-8, 8-4) in walk-off fashion to drop the series.
The Johnnies trailed, 9-6, heading to the seventh inning but rallied, scoring three runs to even the score at nine before the second walk-off home run from Creighton of the series sealed their victory in the game and series, 12-9.
Kaitlin Mattera, Peyton Cody and Kalei Sorensen each hit home runs for the Red Storm on the afternoon. The Johnnies tallied 14 hits in total, as Cody, Gretchen Bowie and Marissa Rizzi racked up three hits apiece.
Mattera and Amelia Ditolvo each had two hits on the afternoon as well, combining for three RBIs.
Erin Brown (3-6) got the start for the Red Storm and worked a quick first frame, but the Bluejays responded in the bottom of the second, stringing together two hits and loading the bases to grab the lead, 3-2, and chase Brown from the contest.
Brown re-entered the game in the circle in the bottom of the seventh, but was unable to record an out, as the first two hitters reached base and a three-run home run from Kailey Wilson won it for Creighton.
The Red Storm will be back in action on Thursday when it takes on Hofstra for the second time this season in Hempstead. First pitch is slated for 3 p.m.